Evaluation of Volume Expansion Therapeutic Effect in Acute Ischemic Stroke

Xiaodong Liu, Xinyu Du, Ran An, Xiaoling Wang, Guangjian Liu, Yi Bao


Background: Volume expansion therapy is widely used in clinical practice, whether expansion therapy has a certain effect on the recovery of neurological function in patients with ischemic stroke is very worth exploring. Our aim is to explore the value of dextran injection in patients with acute ischemic stroke.

Methods: A total of 101 patients with cerebral infarction were divided into two groups: the expansion group and the control group. National Institutes of Health Stroke Scale (NIHSS) scores were assessed at the time of admission and discharge.

Results: There was no statistically significant difference in neurological function improvement between the treatment group and the control group (P > 0.05). Moreover, some factors including age, sex, NIHSS baseline score, systolic blood pressure before treatment, hypertension, diabetes mellitus, coronary heart disease, degree of cerebral arterial stenosis and option of treatment method have no statistically significant contribution to the patients (P > 0.05).

Conclusions: Dextran injection may not improve the degree of neurological deficit in acute ischemic stroke patients.

J Neurol Res. 2019;9(3):23-27
doi: https://doi.org/10.14740/jnr540


Volume expansion therapy; Ischemic stroke; Dextran; NIHSS scores

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