The Importance of Some Possible Somatic and Environmental Risk Factors for the Development of Migraine

Han Le, Peer Tfelt-Hansen, Axel Skytthe, Kirsten Ohm Kyvik, Jes Olesen


Background: The study of risk factors of migraine is important, not least because migraine prevalence seems to increase. The knowledge of risk factors remains limited, however, despite years of research. The objective was to evaluate some possible somatic and environmental risk factors for the development of migraine.

Methods: The Danish Twin Omnibus 1994 and 2002 were questionnaire surveys investigating somatic disorders, lifestyle factors and socioeconomic factors. Both studies used the same validated questions to diagnose migraine. The study population included twin individuals born between 1953 and 1976 who in 1994 reported never to have had migraine. We compared the groups with and without a specific disorder or environmental factor in 1994 with regard to their migraine status in 2002.

Results: This study comprised 13,498 subjects (6,513 men and 6,985 women). The 8-year risk of developing migraine was significantly increased in subjects who already had low back pain (odds ratio (OR) = 1.3; 95% CI = 1.2 - 1.4). Environmental factors associated with an increased risk of development of migraine were low education (OR = 1.3; 95% CI = 1.1 - 1.5), heavy physical workload (OR = 1.1; 95% CI = 1.0 - 1.2), heavy physical recreational activity (OR = 1.2; 95% CI = 1.0 - 1.3) and body mass index (BMI) < 18.5 (OR = 1.3; 95% CI = 1.1 - 1.6). Subjects with weekly or more frequent alcohol consumption had a lower risk of developing migraine compared to subjects with less frequent or no consumption of alcohol (OR = 0.6; 95% CI = 0.6 - 0.7).

Conclusions: This large-scale longitudinal population-based study showed that the risk of development of self-reported migraine was increased in subjects with low back pain, low education, heavy physical workload and heavy physical recreational activity, and decreased in those with frequent alcohol consumption.

J Neurol Res. 2015;5(3):193-198



Migraine; Possible risk factors; Low back pain; Low education; Underweight

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Neurology Research, biannually, ISSN 1923-2845 (print), 1923-2853 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.