Clinical Effect of Leuprolide Acetate, an Agonist of GnRH, on Sensitive and Motor Function in a Patient With Chronic Spinal Cord Injury

J. Luis Quintanar, Maria del Carmen Diaz-Galindo, Denisse Calderon-Vallejo, Irma Hernandez-Jasso

Abstract


The spinal cord is the major conduct through which sensory and motor signals pass between brain and body. Spinal cord injury (SCI) results in a disruption of these pathways and dramatic functional losses. There are different experimental approaches to counteracting the effects of SCI, such as the use of neurotrophic factors. It has been demonstrated that GnRH and its agonist leuprolide acetate (LA) have neurotrophic properties in SCI experimental model animals. Here, we report our findings from a patient suffering chronic SCI, who had undergone treatment with LA therapy. Treatment consisted of intramuscular injection of LA each month during 12 months. An important improvement in sensitive and motor functions was seen in the patient after treatment with LA. Further research is necessary to elucidate the mechanism of action of LA in SCI patients.




J Neurol Res. 2016;6(5-6):111-113
doi: https://doi.org/10.14740/jnr403w


Keywords


Sensitive and motor functions; GnRH; Leuprolide acetate; Spinal cord injury; Neurotrophic factor; ASIA score

Full Text: HTML PDF
 
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


 

     

Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board

Archives

Copyright

Company Profile

Editorial Office

Misconduct and Retraction

Permissions

Company Registration

Contact Us

Abstracting and Indexing

ICMJE

Ownership

Instructions to Authors

Access

Declaration of Helsinki

Contact Publisher

Submission Checklist

Reprints

Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy

Disclaimer

Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians

Careers

Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal

       
       

Journal of Neurology Research, bimonthly, ISSN 1923-2845 (print), 1923-2853 (online), published by Elmer Press Inc.     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.neurores.org   editorial contact: editor@neurores.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

DECLARATION: THIS JOURNAL SITE OUTLOOK IS DESIGNED BY THE PUBLISHER AND COPYRIGHT PROTECTED. DO NOT COPY!