Clinical Features of Chronic Inflammatory Demyelinating Polyneuropathy With Autoimmune Hepatitis

Yi Bao, Yayong Ding, Ran An, Xiaodong Liu, Dianyuzi Xie, Guangjian Liu

Abstract


Chronic inflammatory demyelinating polyneuropathy (CIDP) with autoimmune hepatitis is rare in clinical practice. Here we present a case to describe the relevant clinical features and provide case data for the diagnosis and treatment of the disease. The diagnosis was supported by medical history, physical examination, laboratory and imaging examination, nerve conduction velocity and cerebrospinal fluid examination. The combined disease was identified by autoimmune antibodies and ultrasonography. Combined with the patient’s history of chronic progression, clinical manifestations of peripheral nerve damage, cerebrospinal fluid showing protein-cell separation and nerve conduction velocity showing decreased amplitude and conduction velocity, CIDP was confirmed. Combined with the patient’s examination result of abdominal bulging, color Doppler ultrasound examination showed cirrhosis, positive (+) anti-liver/kidney microsomal type 1 antibody (anti-LKM-1), considering combination of autoimmune hepatitis type II (AIH-II). The clinical symptoms of both were significantly improved by hormone therapy. CIDP is clinically uncommon in elderly male patients, and it is also rare to have AIH-II. But according to the typical pathogenesis, clinical manifestations, detailed physical examination, laboratory and imaging examination, and neuro-immunological data, clinical diagnosis can be made. Pathological data are needed to confirm the diagnosis. Both have poor natural prognosis. However, the use of hormone therapy according to its pathogenesis can effectively alleviate clinical symptoms and prevent progression.




J Neurol Res. 2020;10(1):25-29
doi: https://doi.org/10.14740/jnr542

Keywords


CIDP; Autoimmune hepatitis; LKM-1; Cerebrospinal fluid; Cirrhosis

Full Text: HTML PDF
 

Browse  Journals  

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Neurology Research, bimonthly, ISSN 1923-2845 (print), 1923-2853 (online), published by Elmer Press Inc.            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.neurores.org   editorial contact: editor@neurores.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.