Is Regression of Intracranial Germinoma Spontaneous or Diagnostic Radiation-Induced? A Case Report

Yuichiro Yoneoka, Naoto Watanabe, Masayasu Okada, Kazuhiro Ando, Yukihiko Fujii


Although several case reports describing about “spontaneous” regression of primary intracranial germinoma are available, intensive analysis of those reports suggests diagnostic radiation as a possible cause of the regression in those reports. We present a case of regression of intracranial germinoma, which advocates diagnostic radiation as a cause of previously reported regression of intracranial germinoma. A 22-year-old female student was forced to repeat a grade in school due to unusual fatigue. Despite 4-year absence of her menstrual period as a woman of reproductive age, she did not receive medical attention until experiencing unusual fatigue with visual disturbance and undermined learning. Initial endocrinological work-up revealed panhypopituitarism with masked diabetes insipidus. Magnetic resonance imaging showed a suprasellar tumor, involving the neurohypophysis, optic chiasm and hypothalamus, with spinal dissemination. Endoscopic transnasal biopsy provided pathological confirmation of germinoma, which was treated with craniospinal irradiation. Regression of the suprasellar lesion after cranial computed tomography during radiation therapy planning was demonstrated on serial magnetic resonance imaging. The patient obtained remission and regained a nearly normal level of activity under hormone replacement therapy, but restriction of her visual fields did not improve sufficiently. Diagnostic radiation can induce the regression of intracranial germinoma. Clinicians should keep this diagnostic radiation-induced regression of germinoma in mind and should eliminate unnecessary irradiation to germinoma throughout the diagnostic process. Inadvertent diagnostic radiation can hide fine lesions to be treated.

J Neurol Res. 2014;4(1):41-48


Primary intracranial germinoma; Spontaneous regression; Diagnostic radiation; Diagnostic radiation-induced regression

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Neurology Research, biannually, ISSN 1923-2845 (print), 1923-2853 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.