Progressive Multifocal Leukoencephalopathy and Rituximab: Time to Better Stratify the Risk?

Immovilli Paolo, Rota Eugenia, Morelli Nicola, De Mitri Paola, Terlizzi Emilio, Magnifico Fabiola, Cavanna Luigi, Parmeggiani Maria, Guidetti Donata


Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease emerging as a complication of some novel monoclonal antibody therapies. Disease risk and severity show a wide variability, with fatality ranging from 30% to 90%, probably depending on many risk determinants as demonstrated for natalizumab-associated PML. Rituximab therapy is used to treat hematological malignancies and autoimmune disease, but little is known about PML risk stratification and management. We describe a clinical case with very early diagnosis, extensive treatment, but a fatal outcome, highlighting the need for future studies aimed to better understand PML risk.

J Neurol Res. 2014;4(1):34-36
doi: 10.14740/jnr235w


Progressive multifocal leukoencephalopathy; Rituximab; Risk stratification; Treatment; Diagnosis

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