Cardiovascular Disease Risk Profile in Japanese Midlife Migraineurs

Ken Ikeda, Yuji Kawase, Takanori Takazawa, Osamu Kano, Masaki Tamura, Yasuo Iwasaki


Background: Migraine is a common disabling disorder. A significant association between migraine and cardiovascular disease (CVD) has been reported in European and North American population. Little is known about CVD risk factors in Asian migraineurs. We aimed to clarify CVD risk profile of midlife migraineurs in Japan.  

Methods: A total of 596 subjects (409 women and 187 men) were diagnosed as migraine with aura (MA) and without aura (MO), according to the ICHD-II criteria. CVD risk factors were analyzed on body mass index, west circumference/height, smoking index, blood pressure (BP), serum lipid levels, fasting blood sugar, hemoglobin A1C, C-reactive protein, and a family history of CVD or stroke. Those factors were compared between migraineurs and 599 healthy controls matched by age and sex. 

Results: Mean age (SD) of migraineurs was 44.6 (9.4) years, 44.3 (9.4) in women and 45.2 (9.3) in men. Mean duration of migraine (SD) was 16.7 (11.4) years, 18.7 (12.2) in women and 13.3 (9.1) in men. Frequency and score of migraine attacks were higher significantly in women compared to men (P less than 0.01). As compared to controls, systolic and diastolic BP was significantly increased in female and male migraineurs (P less than 0.01). High-density lipoprotein cholesterol was decreased (P less than 0.01), and total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were increased in sera of female and male migraineurs (P less than 0.01). Serum triglyceride levels were higher in male migraineurs (P less than 0.01). Migraineurs had higher frequency of relatives with CVD or stroke (P less than 0.01). With respect to migraine subtypes, MA and MO sufferers significantly elevated BP (P less than 0.05) and serum levels of TC and LDL-C (P less than 0.01).  

Conclusions: The present study indicated unfavorable CVD risk factors of BP, serum lipid levels and a family history of CVD or stroke in middle-aged migraineurs. The similarity of CVD risk profile was first confirmed between Japanese and Western migraineurs.


Keywords (3-8)*

Migraine; Cardiovascular disease risk profile; Blood pressure; Lipid; Family history of cardiovascular disease or stroke 

Full Text: HTML PDF
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe



Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board



Company Profile

Editorial Office

Misconduct and Retraction


Company Registration

Contact Us

Abstracting and Indexing



Instructions to Authors


Declaration of Helsinki

Contact Publisher

Submission Checklist


Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy


Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians


Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal


Journal of Neurology Research, bimonthly, ISSN 1923-2845 (print), 1923-2853 (online), published by Elmer Press Inc.     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.