Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc
Journal website https://www.neurores.org

Case Report

Volume 10, Number 6, December 2020, pages 240-244

Diffuse Astrocytoma and Ollier’s Disease

Figures

Figure 1.
Figure 1. Brain MRI shows three left frontal cortical based lesions which appear hyperintense on T2 weighted image with mild mass effect but without significant vasogenic edema. The largest lesion shows inhomogeneity with cystic changes and modest enhancement after IV gadolinium administration with tiny ring enhancing focus which shows restricted diffusion. MRI: magnetic resonance imaging; IV: intravenous.
Figure 2.
Figure 2. Brain MRI shows three left frontal cortical based lesions which appear hypointense on T1 weighted image. MRI: magnetic resonance imaging.
Figure 3.
Figure 3. Brain MRI shows a small complex sellar lesion with anterior enhancing component. It is extending into the suprasellar cistern. MRI: magnetic resonance imaging.
Figure 4.
Figure 4. Histopathological examination of the diffuse astrocytoma specimen at intermediate power (× 20) shows an infiltrative growth pattern and microcytic changes.
Figure 5.
Figure 5. Histopathological examination of the diffuse astrocytoma specimen at high power (× 40) show a tumor cells have a more round and uniform appearance with microcytic changes.
Figure 6.
Figure 6. Negative immunohistochemical staining for IDH1. IDH1: isocitrate dehydrogenase 1.
Figure 7.
Figure 7. Ki67 immunohistochemical staining shows from low to focally moderate (up to 6-8%).
Figure 8.
Figure 8. X-ray of the pelvis (AP view) shows ill-defined mixed lytic and sclerotic lesions with chondroid matrix, irregularity and bony destruction affecting mainly the left iliac bone and to a lesser extent the left inferior pubic ramus and the iliac side of the right SI joint. No periosteal reaction nor pathological fracture. AP: anteroposterior; SI: sacroiliac.
Figure 9.
Figure 9. Enhanced chest CT (axial view) shows few nonspecific subpleural nodules in the left upper lobe. There are multiple osseous expansile lesions with popcorn type calcification. CT: computed tomography.

Table

Table 1. Twenty-Five Reported Cases in the Literature Including Our Patient Since 1979
 
StudiesCase yearAge/genderHistology
Bathla et al, 2012 [4]197926/NSGrade II oligoastrocytoma
Bathla et al, 2012 [4]198738/MAstrocytoma
Bathla et al, 2012 [4]198729/MAnaplastic astrocytoma
Bathla et al, 2012 [4]198834/MGrade II astrocytoma
Bathla et al, 2012 [4]199024/MLow grade astrocytoma
Bathla et al, 2012 [4]199129/FHigh grade astrocytoma
Bathla et al, 2012 [4]199423/MAnaplastic astrocytoma
Bathla et al, 2012 [4]199425/MOligodendroglioma
Bathla et al, 2012 [4]199446/MOligoastrocytoma
Bathla et al, 2012 [4]199828/MLow grade astrocytoma
Bathla et al, 2012 [4]199916/MDiffuse brainstem (astrocytoma?)
Bathla et al, 2012 [4]199923/Fpons involvement (astrocytoma?)
Bathla et al, 2012 [4]199928/?Low grade astrocytoma?
Bathla et al, 2012 [4]20027/FLow grade astrocytoma
Bathla et al, 2012 [4]200421/FLow grade fibrillary astrocytoma
Bathla et al, 2012 [4]200628/FAnaplastic mixed oligoastrocytoma
Bathla et al, 2012 [4]200814/MAnaplastic astrocytoma.
Bathla et al, 2012 [4]20096/FGlioblastoma multiforme
Hori et al, 2010 [8]20104/MAnaplastic astrocytoma
Bathla et al, 2012 [4]201019/MGrade III anaplastic astrocytoma
Bathla et al, 2012 [4]201216/MGrade II glioma
Khan et al, 2013 [7]201335/MLow grade astrocytoma
Rebecca et al, 2016 [6]201626/MAnaplastic oligodendroglioma
Gajavelli et al, 2016 [9]201655/FAnaplastic astrocytoma
Present study202023/FGrade II astrocytoma