J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website http://www.neurores.org

Original Article

Volume 10, Number 1, February 2020, pages 7-12

The Association Between Hyperparathyroidism and Ischemic Stroke Subtypes

**Table 1.** Demographic and Clinical Features of the Study Group With Ischemic Stroke (n = 158)
	Mean ± SD
Age, year	71.5 ± 11.5
Gender (female/male)	79/79
Parathormone, pg/mL	67.7 ± 42.5
F/M: female/male; SD: standard deviation; LAA: large-artery atherosclerosis. *P < 0.05.
Large vessel imaging
Normal large vessel	131 (82.9%)
Stenosis > 50%	13 (8.2%)
Stenosis > 70%	14 (8.9%)
Stroke classification
LAA (intracranial)	56 (35.4%)
LAA (extracranial)	8 (5%)
Cardioembolism	37 (23.4%)
Lacune	52 (32.9%)
Stroke of other determined etiology	0 (0%)
Stroke of undetermined etiology	5 (3.2%)
Hypertension	130 (82.3%)
Hyperlipidemia	54/158 (34.2%)
Diabetes mellitus	56/158 (35.4)
Myocardial infarction	4/158 (2.5%)
Coronary artery disease	36 (22.8%)
Atrial fibrillation	43 (27.2%)

Table 1. Demographic and Clinical Features of the Study Group With Ischemic Stroke (n = 158)

Mean ± SD

Age, year

71.5 ± 11.5

Gender (female/male)

79/79

Parathormone, pg/mL

67.7 ± 42.5

N (%)

F/M: female/male; SD: standard deviation; LAA: large-artery atherosclerosis. *P < 0.05.

Large vessel imaging

Normal large vessel

131 (82.9%)

Stenosis > 50%

13 (8.2%)

Stenosis > 70%

14 (8.9%)

Stroke classification

LAA (intracranial)

56 (35.4%)

LAA (extracranial)

8 (5%)

Cardioembolism

37 (23.4%)

Lacune

52 (32.9%)

Stroke of other determined etiology

0 (0%)

Stroke of undetermined etiology

5 (3.2%)

Hypertension

130 (82.3%)

Hyperlipidemia

54/158 (34.2%)

Diabetes mellitus

56/158 (35.4)

Myocardial infarction

4/158 (2.5%)

Coronary artery disease

36 (22.8%)

Atrial fibrillation

43 (27.2%)

**Table 2.** Comparisons of the Demographic and Clinical Features Between High PTH Group and Normal PTH Group of Patients
			High PTH group (n = 31)	Normal PTH group (n = 127)	P value
PTH: parathormone; Intra: intracranial atherosclerosis; Extra: extracranial atherosclerosis. ^aThere is a significant difference between the variables indicated; ^bThere is no significant difference between the variables. *P < 0.05.
Age			70.3	76	0.165
Gender (female/male)			19/12	60/67	0.115
PTH level			135.2 ± 48.8 pg/mL	51.2 ± 17.2 pg/mL	0.000
Stroke classification	Large vessel disease	Intra	5^a	51^a	0.008*
		Extra	4^a	4^a
	Cardioembolic		12^a	25^a
	Small vessel occlusion		10^b	42^b
	Stroke of other determined etiology		0^b	0^b
	Stroke of undetermined etiology		0^b	5^b
Hypertension			26/31	104/127	0.515
Hyperlipidemia			10/31	44/127	0.490
Diabetes mellitus			10/31	46/127	0.424
Myocardial infarction			0/31	4/127	0.414
Coronary artery disease			8/31	28/127	0.408
Atrial fibrillation			14/31	29/127	0.013*

Table 2. Comparisons of the Demographic and Clinical Features Between High PTH Group and Normal PTH Group of Patients

High PTH group (n = 31)

Normal PTH group (n = 127)

P value

PTH: parathormone; Intra: intracranial atherosclerosis; Extra: extracranial atherosclerosis. ^aThere is a significant difference between the variables indicated; ^bThere is no significant difference between the variables. *P < 0.05.

Age

70.3

0.165

Gender (female/male)

19/12

60/67

0.115

PTH level

135.2 ± 48.8 pg/mL

51.2 ± 17.2 pg/mL

0.000

Stroke classification

Large vessel disease

Intra

5^a

51^a

0.008*

Extra

4^a

Cardioembolic

12^a

25^a

Small vessel occlusion

10^b

42^b

Stroke of other determined etiology

0^b

Stroke of undetermined etiology

0^b

5^b

Hypertension

26/31

104/127

0.515

Hyperlipidemia

10/31

44/127

0.490

Diabetes mellitus

10/31

46/127

0.424

Myocardial infarction

0/31

4/127

0.414

Coronary artery disease

8/31

28/127

0.408

Atrial fibrillation

14/31

29/127

0.013*

**Table 3.** Multiple Logistic Analysis of Potential Risk Factors and Diseases Associated With Ischemic Stroke due to Extracranial Atherosclerosis and Other Subtypes
Risk factors	Extracranial atherosclerosis (n = 8)	Other subtypes (n = 150)	Odds ratio (95% CI)	P value
CI: confidence interval. *P < 0.05.
Hypertension	6/8	124/150	0.860 (0.120 - 6.167)	0.881
Hyperlipidemia	4/8	50/150	2.819 (0.573 - 13.876)	0.202
Diabetes mellitus	2/8	54/150	0.353 (0.052 - 2.393)	0.286
Myocardial infarction	0/8	4/150	5.440 (0.000 - 0.000)	1.000
Coronary artery disease	0/8	36/150	0.000 (0.000 - 0.000)	0.998
Atrial fibrillation	2/8	41/150	0.539 (0.085 - 3.435)	0.513
Gender (female/male)	5/3	74/76	2.266 (0.425 - 12.095)	0.338
PTH level (high/normal)	4/4	27/123	0.164 (0.034 - 0.788)	0.024*

Table 3. Multiple Logistic Analysis of Potential Risk Factors and Diseases Associated With Ischemic Stroke due to Extracranial Atherosclerosis and Other Subtypes

Risk factors

Extracranial atherosclerosis (n = 8)

Other subtypes (n = 150)

Odds ratio (95% CI)

P value

CI: confidence interval. *P < 0.05.

Hypertension

6/8

124/150

0.860 (0.120 - 6.167)

0.881

Hyperlipidemia

4/8

50/150

2.819 (0.573 - 13.876)

0.202

Diabetes mellitus

2/8

54/150

0.353 (0.052 - 2.393)

0.286

Myocardial infarction

0/8

4/150

5.440 (0.000 - 0.000)

1.000

Coronary artery disease

0/8

36/150

0.000 (0.000 - 0.000)

0.998

Atrial fibrillation

2/8

41/150

0.539 (0.085 - 3.435)

0.513

Gender (female/male)

5/3

74/76

2.266 (0.425 - 12.095)

0.338

PTH level (high/normal)

4/4

27/123

0.164 (0.034 - 0.788)

0.024*