Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc
Journal website http://www.neurores.org

Original Article

Volume 8, Number 3, November 2018, pages 19-25

Is Epstein-Barr Virus a Risk Factor for Multiple Sclerosis?

Figure

Figure 1.
Figure 1. Comparison between the serum levels of EBV biomarkers: anti-EBV-viral capsid antigen (VCA)-IgG, anti-EBV-early antigen (EA)-IgG and anti-EBV- EBV nuclear antigen 1 antibody (EBNA1)-IgG of both patients and controls with no significant difference between both groups.

Tables

Table 1. The Relations Between EBV Titers in MS Patients and History of Previous Viral Infection
 
Viral infectionT valueP value
Negative (n = 19)Positive (n = 22)
Anti-EBV-VCA-IgG30.79 ± 63.77140.00 ± 54.77-0.4980.622
Anti-EBV-EA-IgG52.63 ± 38.1756.23 ± 35.26-0.3130.756
Anti-EBV-EBNA1-IgG27.04 ± 32.9215.12 ± 10.431.5140.145

 

Table 2. The Relation Between EBV Levels and Different Types of MS
 
CIS (n = 8)RRMS (n = 31)PPMS (n = 2)P value
Anti-EBV-VCA-IgG137.38 ± 56.70135.68 ± 61.77130.00 ± 0.00.988
Anti-EBV-EA-IgG47.00 ± 16.0457.90 ± 40.3433.00 ± 9.900.528
Anti-EBV-EBNA1-IgG32.75 ± 48.5218.04 ± 13.2212.50 ± 2.120.278

 

Table 3. The Relation Between EBV Titers and MS Relapses
 
Relapses occurrenceP value
Negative (n = 12)Positive (n = 29)
Anti-EBV-VCA-IgG135.7 ± 62.2135.7 ± 58.10.874
Anti-EBV-EA-IgG59.6 ± 42.652.45± 33.80.667
Anti-EBV-EBNA1-IgG27.5 ± 39.717.8 ± 13.50.807