Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc
Journal website http://www.neurores.org

Original Article

Volume 7, Number 6, December 2017, pages 103-107


Calcitonin Gene-Related Peptide as a Biomarker in Migraine

Tables

Table 1. Comparison Between the Four Studied Groups According to CGRP
 
Chronic migraine (n = 20)Episodic migraine (n = 20)Tension type and cluster headache (n = 20)Control (n = 20)FP
F: F value for ANOVA. Sig. between groups was done using post hoc test. PControl: P value for comparing between control and each group. P1: P value for comparing between chronic migraine and episodic migraine. P2: P value for comparing between chronic migraine and tension type and cluster headache. P3: P value for comparing between episodic and tension type and cluster headache. *Statistically significant at P ≤ 0.05. F(3,76) = 2.725.
CGRP
  Min. - Max.131.8 - 194.669.6 - 121.962.8 - 110.851.7 - 83.65155.09*< 0.001*
  Mean ± SD165.0 ± 17.994.1 ± 17.8387.2 ± 13.870.5 ± 8.36
  Median167.3897.086.9570.63
PControl< 0.001*< 0.001*0.004*
Sig. between groupsP1 < 0.001*, P2 < 0.001*, P3 = 0.471

 

Table 2. Relation Between CGRP and Aura in Each Group
 
CGRPAuratP
NoYes
t, P: t and P values for Student’s t-test for comparing between the two groups. *Statistically significant at P ≤ 0.05. T(18) = 2.101.
Chronic migrainen = 17n = 3
  Min. - Max.131.80 - 186.0185.45 - 194.603.493*0.003*
  Mean ± SD160.30 ± 14.93191.32 ± 5.09
  Median157.80193.90
Episodic migrainen = 16n = 4
  Min. - Max.69.60 - 121.90100.70 - 116.303.407*0.005*
  Mean ± SD90.16 ± 17.56109.88 ± 7.54
  Median93.05111.25

 

Table 3. Correlation Between CGRP and Different Parameters in Each Group
 
Group parameterCGRP
Chronic migraineEpisodic migraineTension type and cluster headacheControl
r: Pearson coefficient.
Age (years)
  r-0.252-0.199-0.008-0.123
  P0.2850.4000.9730.607
Severity
  r0.0850.1890.354-
  P0.7210.4260.125-
Frequency/month
  r-0.0920.0880.089-
  P0.7000.7120.710-
Duration/attack (h)
  r0.1290.0770.235-
  P0.5880.7480.319-