Figure 1. The isobolographic analysis of pharmacodynamic interactions [13].
| Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc |
| Journal website http://www.neurores.org |
Review
Volume 5, Number 6, December 2015, pages 267-276
Evidence for Efficacy of Combination of Antiepileptic Drugs in Treatment of Epilepsy
Figures
Table
| Author | Efficacy | Toxicity | |
|---|---|---|---|
| Classical AEDs | |||
| VPA + ESM | Bourgeois [12] | Additive | Infra-additive |
| CBZ + VPA | Bourgeois [24] | Additive | Infra-additive |
| PB + VPA | Bourgeois [24] | Additive | Additive |
| CBZ + PB | Bourgeois [25] | Additive | Additive |
| PHT+ PB | Weaver [26] Masuda [27] Bourgeois [28] | Supra-additive Supra-additive Additive | Additive No information Infra-additive |
| VPA + PHT | Chez [29] | Supra-additive | Additive |
| Classical + novel AEDs | |||
| TPM + (CBZ/PB) | Shank [30] | Supra-additive | No information |
| TPM + PHT | Shank [30] | Additive | No information |
| GBP + (CBZ/VPA/PHT/PB) | Borowicz [31] | Supra-additive | Additive |
| FBM + PB | Borowicz [32] | Supra-additive | No information |
| ZNS + (VPA/PHT) | Borowicz [33] | Supra-additive/additive | No information |
| ZNS + (PB/CBZ) | Borowicz [33] | Additive | No information |
| LEV + (VPA/CLZ/PB/ESM) | Dudra-Jastrzebska [34] | Supra-additive | No information |
| STP + VPA | Luszczki [35] | Infra-additive | No information |
| STP + CLB | Luszczki [35] | Additive | No information |
| STP + CBZ | Luszczki [36] | Supra-additive/additive/infra-additive | No information |
| PGB + CBZ | Luszczki [37] | Additive | No information |
| TGB + VPA | Luszczki [38] | Additive (pharmacodynamic) | No information |
| TGB + VPA | Luszczki [39] | Supra-additive (pharmacokinetic) | No information |
| OXC + PHT | Luszczki + Czuczwar [40] | Infra-additive | No information |
| OXC + CLZ | Luszczki + Czuczwar [40] | Supra-additive/infra-additive | No information |
| OXC + (CBZ/VPA/PB) | Luszczki + Czuczwar [40] | Additive | No information |
| LMG + PB | Luszczki [41] | Supra-additive | Supra-additive |
| LMG + PHT | Luszczki [41] | Additive | No information |
| LMG + VPA | Luszczki [41] | Supra-additive | No information |
| Novel AEDs | |||
| TPM + LMG | Luszczki [41] | Supra-additive | Infra-additive |
| GBP + LMG | Borowicz [31] | Supra-additive | No information |
| LEV + GBP | Dudra-Jastrzebska [42] | Supra-additive | No information |
| LEV + (TGB/VGB) | Dudra-Jastrzebska [42] | Additive | No information |
| PGB + (TGB/VGB) | Luszczki [43] | Supra-additive/additive | No information |
| PGB + (LEV+VGB) | Luszczki [43] | Additive | No information |
| PGB + (LMG/OXC/TPM) | Luszczki [44] | Additive | No information |
| LEV + FBM | Luszczki [45] | Supra-additive | No information |
| TPM + GBP | Luszczki [46] | Supra-additive | Additive |
| VGB + TGB | Luszczki + Czuczwar [47] | Supra-additive (PTZ)/additive (MES) | No information |
| TPM + FBM | Luszczki + Czuczwar [48] | Supra-additive | Infra-additive |
| TPM + OXC | Luszczki + Czuczwar [48] | Supra-additive | Additive |
| OXC + FBM | Luszczki + Czuczwar [48] | Infra-additive | Additive |
| OXC + LMG | Luszczki + Czuczwar [48] | Infra-additive | Supra-additive |
| TGB + GBP | Luszczki + Czuczwar [49] | Supra-additive | Additive |