J Neurol Res

Journal of Neurology Research, ISSN 1923-2845 print, 1923-2853 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Neurol Res and Elmer Press Inc

Journal website http://www.neurores.org

Original Article

Volume 5, Number 1-2, April 2015, pages 160-166

Evaluation of the Frequency and Intensity of Osmophobia Between Headache Attacks in Migraine Patients Through an Osmophobia Diary

**Table 1.** Distribution of Sex and Age According to Diagnosis of 200 Patients With Migraine Without Aura and 200 With Episodic Tension-Type Headache
Variables	Diagnostic	P value
MWA: migraine without aura; ETTH: episodic tension-type headache; CI: confidence interval. *P value based on the Chi-square test; ^†P value by the Mann-Whitney test for average difference test between averages of unpaired samples.
Sex			< 0.001*
Female (n, %)	182 (91.0)	37 (18.5)
Male (n, %)	18 (9.0)	163 (81.5)
Age (years)			0.008^†
Mean	37.3 (9.0)	40.0 (10.4)
95% CI	36.0 - 38.6	38.5 - 41.4

Table 1. Distribution of Sex and Age According to Diagnosis of 200 Patients With Migraine Without Aura and 200 With Episodic Tension-Type Headache

Variables

Diagnostic

P value

MWA

ETTH

MWA: migraine without aura; ETTH: episodic tension-type headache; CI: confidence interval. *P value based on the Chi-square test; ^†P value by the Mann-Whitney test for average difference test between averages of unpaired samples.

Sex

< 0.001*

Female (n, %)

182 (91.0)

37 (18.5)

Male (n, %)

18 (9.0)

163 (81.5)

Age (years)

0.008^†

Mean

37.3 (9.0)

40.0 (10.4)

95% CI

36.0 - 38.6

38.5 - 41.4

**Table 2.** Presence of Osmophobia Between Headache Attacks in 200 Patients With Migraine Without Aura and 200 With Episodic Tension-Type Headache
Symptom	Diagnosis	P value
MWA: migraine without aura; ETTH: episodic tension-type headache. ^aP value by Chi-square test.
Osmophobia between headache attacks	48	24.0	0	0.0	< 0.014^a
Female	37	20.3	0	0.0
Male	11	61.1	0	0.0

Table 2. Presence of Osmophobia Between Headache Attacks in 200 Patients With Migraine Without Aura and 200 With Episodic Tension-Type Headache

Symptom

Diagnosis

P value

MWA

ETTH

MWA: migraine without aura; ETTH: episodic tension-type headache. ^aP value by Chi-square test.

Osmophobia between headache attacks

24.0

0.0

< 0.014^a

Female

20.3

0.0

Male

61.1

0.0

**Table 3.** Distribution of 748 Episodes of Osmophobia According to the Frequency and Intensity for 30 Days in 48 Migraine Patients
Variables	Episodes of osmophobia
VAS: visual analog scale.
Days with osmophobia	748 (100.0)	15.6 ± 6.8	13.7 - 17.5
Mild (VAS 1 - 4)	117 (15.6)	2.4 ± 3.4	1.4 - 3.4
Moderate (VAS 5 - 7)	171 (22.9)	3.6 ± 3.4	2.6 - 4.5
Severe (VAS 8 - 9)	264 (35.3)	5.5 ± 3.9	4.4 - 6.6
Very severe (VAS 10)	196 (26.2)	4.1 ± 3.2	3.2 - 5.0

Table 3. Distribution of 748 Episodes of Osmophobia According to the Frequency and Intensity for 30 Days in 48 Migraine Patients

Variables

Episodes of osmophobia

Number of days (n, %)

Average

95% CI

VAS: visual analog scale.

Days with osmophobia

748 (100.0)

15.6 ± 6.8

13.7 - 17.5

Mild (VAS 1 - 4)

117 (15.6)

2.4 ± 3.4

1.4 - 3.4

Moderate (VAS 5 - 7)

171 (22.9)

3.6 ± 3.4

2.6 - 4.5

Severe (VAS 8 - 9)

264 (35.3)

5.5 ± 3.9

4.4 - 6.6

Very severe (VAS 10)

196 (26.2)

4.1 ± 3.2

3.2 - 5.0

**Table 4.** Distribution of the Frequency and Intensity of Osmophobia Between Attacks for 30 Days in 48 Migraine Patients
Patient	Frequency (days)	Intensity	OI^a
VAS: visual analog scale; OI: osmophobia index. ^aTo calculate the osmophobia index, we multiplied the amount of mild, moderate, severe and very severe intensities, respectively, by the scores 1, 2, 3 and 4.
1	6	1	0	2	3	19
2	17	3	7	7	0	38
3	23	4	4	5	10	67
4	12	0	0	4	8	44
5	21	3	10	4	4	51
6	5	0	0	0	5	20
7	18	2	3	8	5	52
8	10	0	3	3	4	31
9	20	1	0	12	7	65
10	24	3	11	5	5	60
11	5	0	0	0	5	20
12	20	2	4	0	14	66
13	25	3	14	5	3	58
14	6	1	0	4	1	17
15	10	0	0	0	10	40
16	18	2	3	8	5	52
17	12	0	2	5	5	39
18	17	2	3	7	5	49
19	10	0	0	8	2	32
20	16	2	3	7	4	45
21	12	1	1	10	0	33
22	24	11	7	3	3	36
23	16	4	3	9	0	37
24	21	0	6	15	0	57
25	9	0	3	5	1	25
26	5	0	0	5	0	15
27	24	3	10	6	5	61
28	12	0	1	1	10	45
29	22	0	3	15	4	67
30	18	0	3	8	7	58
31	18	2	3	8	5	56
32	5	0	4	0	1	12
33	18	0	3	5	10	61
34	20	12	8	0	0	28
35	10	4	1	5	0	21
36	25	10	6	9	0	49
37	15	15	0	0	0	15
38	20	2	4	9	5	57
39	16	2	3	7	4	45
40	3	0	0	0	3	12
41	22	3	4	10	5	61
42	20	8	4	5	3	46
43	20	0	6	9	5	59
44	5	1	1	0	3	15
45	25	3	5	11	6	70
46	24	5	11	3	5	56
47	20	2	4	9	5	57
48	4	0	0	3	1	13

Table 4. Distribution of the Frequency and Intensity of Osmophobia Between Attacks for 30 Days in 48 Migraine Patients

Patient

Frequency (days)

Intensity

OI^a

Mild (VAS 1 - 4)

Moderate (VAS 5 - 7)

Severe (VAS 8 - 9)

Very severe (VAS 10)

VAS: visual analog scale; OI: osmophobia index. ^aTo calculate the osmophobia index, we multiplied the amount of mild, moderate, severe and very severe intensities, respectively, by the scores 1, 2, 3 and 4.